|
KMID : 0613820180280040496
|
|
Journal of Life Science
2018 Volume.28 No. 4 p.496 ~ p.507
|
|
|
Efficient Delivery of Toxoid Antigens using Micro/Nano-carriers
|
|
Park Ga-Young
Ahn Gn-A
Lee Se-Hee
Kim Sang-Bum
Kim Yang-Hoon
Ahn Ji-Young
|
|
|
Abstract
|
|
|
|
Immunization has been performed for centuries and is generally accepted as a sustainable method of controlling bacteria, viruses, and mediated and infectious diseases. Despite many studies having been performed on animal subjects to demonstrate the importance of toxin immunity, the use of toxoid vaccines in humans and animals has been limited for a long time. Recently, the development of the toxoid antigen delivery system has been facilitated using novel nano-medicinal technology. The micro/nano-carrier has been used to improve vaccination coverage as well as reduce vaccine costs. A micro/nano-carrier is a micro/nano-sized material that delivers immune cargo, including recombinant or peptide toxoid antigens. These toxoid antigens are either encapsulated in the interior or displayed on the surface of micro/nano-carriers as a way to protect them from the cellular machinery. In particular, the combination of toxoid antigens and micro/nano-carriers can induce phagocytosis through the specific interactions between GCs and macrophages; thus, the toxoid antigens can be delivered easily into the macrophages. This paper reviews recent achievements of micro/nano-carriers in the field of vaccine delivery systems such as microbial ghost cells (GCs, Bacterial ghost cells and Yeast ghost cells), gene-manipulated outer membrane vesicles (OMVs) and biocompatible, polymer-based nanoparticles (NPs, NP-Carrier and NP-Cage). Finally, this review shows various aspects in terms of the hosts’ immune responses.
|
|
|
KEYWORD
|
|
|
Ghost cells (GCs), micro/nano carrier, nanoparticles (NPs), outer membrane vesicles (OMVs), toxoid antigen
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|